TL;DR
After four years of consistent use, this review concludes that Perricone MD is a worthwhile investment for those serious about anti-aging, especially their high-performance eye creams and targeted treatments. While the luxury price tag can cause sticker shock, the brand’s science-backed, potent formulas—like the Cold Plasma Plus+ collection and Vitamin C Ester line—deliver visible improvements in firmness, brightness, and texture. Not every product suits all skin types, but for those targeting fine lines, wrinkles, and dullness, the results justify the cost.
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Your Ultimate Review For Perricone MD Starts Here!
I’ve been using Perricone MD products for about four years now. My journey began when my skin guru applied one of their eye creams and moisturizers on me after a microdermabrasion session.
As someone who values eye creams—especially for mature skin, since the eyes show the most visible signs of aging like pesky fine lines and wrinkles—I always start by testing eye creams when exploring a new skincare brand.
When I first investigated Perricone MD, I tried a few different eye creams. After seeing great results in improving skin tone, reducing puffiness, and and tired unde reyes, I felt confident enough to explore their other skincare products.
Overall, my experience with Perricone MD has been pretty positive. Some products, like their night creams and targeted eye creams, have become staples in my routine. However, a few others didn’t work as well for my combination and oily skin and felt a bit underwhelming.
Is Perricone MD’s Luxe Price Tag Worth It?
When I first discovered Perricone MD, the price of their eye creams definitely caused some sticker shock. I was already using another luxe brand, Repasage, but I was eager to find the holy grail of eye creams—something powerful enough to turn back the page and rewind the clock.
I’ve had good results with some drugstore eye cream gems, but for dramatic, visible results, many luxe brands—including Perricone MD—offer superior ingredient formulations that truly address the most visible signs of fine lines, wrinkles and loss of collagen.
That said, not all luxe brands perform equally. I’ve found some superstar Perricone products, as well as a few that didn’t quite meet my expectations (read on for my full product reviews).
Perricone MD Powerhouse Eye Creams That Deliver Results
When I first stepped into the world of Perricone MD, I bought several eye creams. Two have stood the test of time and continue to deliver dramatic results every morning and night: the Vitamin C Ester CCC+ Ferulic Brightening Under-Eye Cream and the Hypoallergenic Clean Correction Firming & Brightening Eye Cream.
The Vitamin C Ester eye cream is my go-to for daytime. It dramatically diminishes the appearance of dark circles, puffiness, and wrinkles while providing intense hydration. It also works beautifully as a base for powder or concealer—perfect for those long nights when I need a little extra rewind action.
The Hypoallergenic Firming & Brightening Eye Cream is my night-time favorite. It not only reduces dark circles, puffiness, and wrinkles but also offers superior hydration that I love having on my eyes while I sleep while my skin regenerates.
Note: Both eye creams work wonders any time of day, but I prefer this specific day-and-night routine for optimal results.
Holy Grail Status: See the Live Results
Forget photos—this is the Perricone MD Hypoallergenic Eye Cream in action, delivering results live! I apply a tiny amount to one eye so you instantly see the moisturizing glow as the active ingredients penetrate. This is my nighttime go-to for firming, brightening, and reducing dark circles, helping you wake up looking truly refreshed.
The Honest, Full Review of Perricone MD Products I’ve Tried
Here’s my honest review of all the Perricone MD products I’ve tried, based on my personal experience and skin type.
Get ready for a quick-fire rundown of what worked, what didn’t, and how these products addressed various skin concerns like dryness, uneven texture, and fine lines.
Acne Relief Gentle Exfoliating Toner
- Cleanses deeply and tightens pores without harshly stripping skin. Used to be my go-to but I ran into the item running out-of-stock pretty frequently.
No Rinse Micellar Cleansing Water.
- Gentle on skin. No residue left behind. My go-to for eye makeup remover.
Hypoallergenic Clean Correction Firming & Brightening Eye Cream.
- Brightens and diminishes dark circles. deeply Hydrates the skin. My nightly go-to.
Vitamin C Ester CCC+ Ferulic Brightening Under-Eye Cream
- Brightens dark circles. Tightens under eyes. Gives dewy glow. My daytime go-to.
Vitamin C Ester Brightening Eye Serum.
- Lightly moisturizes the under eyes. Slightly brightens. Not my favorite as the results don’t compare to many other Perricone MD eye products.
Cold Plasma Plus+ Advanced Eye Cream.
- Simple eye cream. Moisturizes very well. Good product, not my go-to.
Essential Fx Acyl-Glutathione Eyelid Lift Serum
- Tightens and leaves eyes with a plump lifted feel. Good product, not my go-to.
Hypoallergenic Clean Correction Ultra-Lightweight Calming Veil Broad Spectrum SPF 35
- My daily go-to SPF. Non-greasy. Moisturizes without leaving residue. Love pairing with a drop of the Essential Fx Acyl-Glutathione Chia Oil.
Vitamin C Ester Photo-Brightening Moisturizer Broad Spectrum SPF 30.
- Brightens skin a little. A little goes a long way. Moisturizes very well. A little greasy looking if I use more than a little.
High Potency Face Finishing & Firming Moisturizer Broad Spectrum SPF 30
- Moisturizing SPF. Light and non-greasy. Solid product.
Hypoallergenic Clean Correction Barrier Repair Nourishing Moisturizer.
- Calms redness. Moisturizes very well. A little goes a long way. My go-to moisturizer when not going out into the sun.
High Potency Growth Factor Firming & Lifting Serum
- Tightens and leaves skin with a plump lifted feel. Solid Product.
Essential Fx Acyl-Glutathione Chia Oil.
- A tiny drop goes a long way. Deeply hydrates. Smooths skin texture and works magic on smoothing the look/texture of facial scars. My daily go-to.
The Perricone MD Cold Plasma Plus Collection
Cold Plasma Plus+ Hand Therapy.
- Solid hand cream. No left over greasy residue.
Cold Plasma Plus+ Lip Therapy.
- Deeply hydrates. Hyaluronic acid lightly plumps lips. My go-to daily lip treatment.
Cold Plasma Plus+ Concentrated Treatment Sheet Mask.
- Deeply moisturizes and plumps skin.
- Moisturizes deeply. Tightens skin. Use at night for all-night deep hydration. Definitely a superior product for décolleté anti aging.
Cold Plasma Plus+ Daily Defense Moisturizer Broad Spectrum SPF 35.
- A little goes a long way. Moisturizes very well. A little greasy looking if I use more than a little.
Cold Plasma Plus+ Detox Clay Cleanser.
- Diminishes dirty pores. Leaves my skin clean and pores minimized.
Where to Order Perricone MD Products
Years ago, my favorite skincare essentials were only available through select med spas or specialty retailers, which worked back then but isn’t ideal for faster fast-paced life. What I truly appreciate now is how accessible Perricone MD has become—you can effortlessly purchase their products online, either directly from their official retail store or through their Amazon storefront.
Both options offer their perks, but Amazon slightly takes the lead with its fast 2-day delivery, subscribe & save discounts, and exclusive bundles and promotions on the Perricone MD Amazon store. This makes it super easy to keep your skincare routine stocked with high-quality Perricone MD products, so your skin stays hydrated, radiant, and soft every day.
Who Is Dr. Perricone? The Skincare Expert Behind the Brand
This whole blog piece is about this standout brand of skincare products, but who the heck is Dr. Perricone?, lol. He’s a dermatologist, author, and all-around skincare guru who built his whole career on the idea that inflammation is at the root of aging. He’s written a bunch of books and obviously, ha, created his own line of products—Perricone MD—that focus on keeping skin actually healthy.
Basically, he’s one of the first people to say: “Hey, what you eat, what supplements you take, and what you put on your skin all matter.” Which… turns out, is pretty spot on.
If you want to do a deeper dive into his background (and see his official bio), you can check it out here.
Final Thoughts on Perricone MD: Worth the Investment?
After four years of incorporating Perricone MD into my skincare routine, I can confidently say that despite the luxury price tag, many of their products deliver visible, impressive results that justify the investment. Their eye creams stand out as true heroes for addressing dark circles, puffiness, and fine lines—the most visible signs and appearance of aging around the eyes.
While not every product is a perfect fit for me, the superior ingredient formulations and targeted benefits make Perricone a brand worth considering if you’re serious about elevating your skincare routine and improving your skin’s appearance. Whether you order from their official store or the convenient 2-day shipping from their Amazon store, Perricone MD has accessible options for anyone looking to combat aging and maintain radiant skin.
Now Go Get Your Glow On.
—Brian
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Is Perricone MD Worth It?
Is Perricone MD Worth It?
Yes, Perricone MD is absolutely worth it for those targeting specific skin concerns with clinically-backed, potent formulas. The brand consistently delivers noticeable results, with users of cult-favorites like the Cold Plasma Plus+ and Hyaluronic Serum reporting significant improvements in smoothness, radiance, and overall tone. While the high-end price makes it a financial investment, the luxurious feel and proven efficacy of their core lines make it justifiable for anyone who values moving from good skin to great skin; for me, the Vitamin C Ester CCC + Ferulic Brightening Under-Eye Cream is a total holy grail.
Is Perricone MD Worth It For Wrinkles?
Is Perricone MD Worth It For Wrinkles?
Perricone MD is widely regarded as worth the investment for wrinkles, Yes, Perricone MD is often considered worth it for targeting wrinkles and other advanced signs of aging due to its potent, clinically-backed formulas, especially within the popular Cold Plasma Plus+ line. Products like the Advanced Serum Concentrate use ingredients like copper tripeptides, vitamin C ester, and omegas to target multiple concerns, with clinical studies showing significant improvements in fine lines and wrinkles, as well as firmness and texture. While the price point is high, many users find the rapid and noticeable age-defying results, including the smoothing of lines and a more youthful look, justify the investment.
Where Can I Buy Perricone MD Products?
Where Can I Buy Perricone MD Products?
You can purchase Perricone MD products directly from their official website as well as from major authorized retailers and department stores like Amazon, Ulta Beauty, and Nordstrom.
Does Perricone MD Products Ever Go On Sale?
Does Perricone MD Products Ever Go On Sale?
Yes, Perricone MD products frequently go on sale both on their official website and through authorized retailers like Amazon, Ulta Beauty, and Nordstrom, often offering significant savings. The official website regularly holds sitewide sales with discounts of 30% to 40% off and maintains a dedicated Clearance section for deeper markdowns; the biggest discounts are typically found during major shopping holidays like Black Friday and Cyber Monday.
What Perricone MD Products Are The Best?
What Perricone MD Products Are The Best?
The best Perricone MD products are generally those from the Cold Plasma Plus+ and High Potency Classics collections, which are their most highly-rated and effective formulas. The top-selling, cult-favorite products often cited by users and reviewers for delivering visible results include the Cold Plasma Plus+ Advanced Serum Concentrate for all-in-one anti-aging, the High Potency Hyaluronic Intensive Hydrating Serum for deep moisture, and the Cold Plasma Plus+ Sub-D Neck cream for firming the jawline and neck area. You also have great success with the Vitamin C Ester line, which is known for powerful brightening and smoothing, especially the Vitamin C Ester CCC + Ferulic Brightening Complex 20%.
What is DMAE?
What is DMAE?
DMAE, which stands for Dimethylaminoethanol, is a compound DMAE, or dimethylaminoethanol, is an organic compound that occurs naturally in the body and certain fish; in skincare, it is a popular anti-aging ingredient celebrated for its firming and lifting effects. It is believed to work by stimulating the production of acetylcholine, a neurotransmitter that influences muscle tone, which results in a visibly tightened and smoothed appearance on the skin, often giving an almost immediate lift. Clinical studies have shown that daily application of DMAE can lead to significant reductions in forehead lines and fine wrinkles, as well as improving overall skin firmness and tone over time, though some users with sensitive skin may experience mild tingling.
Does Perricone MD Use DMAE?
Does Perricone MD Use DMAE?
Yes, Perricone MD prominently uses DMAE (dimethylaminoethanol) as one of its signature, science-backed ingredients in many of its skin-firming and anti-aging products. The brand leverages DMAE’s ability to help visibly lift and firm sagging skin and notes that it acts as an antioxidant to help protect against environmental aggressors. You can find this ingredient in several popular lines, particularly the High Potency Classics (like the Face Finishing & Firming Moisturizer and Face Firming Serum and the Cold Plasma Plus+ line (like the Sub-D Neck cream, as the company combines it with other powerful ingredients like Alpha Lipoic Acid and Vitamin C Ester to maximize visible results.
What Is The 1/2/3 Rule For Retinol?
What Is The 1/2/3 Rule For Retinol?
The 1-2-3 rule for retinol is a recommended method for slowly introducing the powerful ingredient into your skincare routine to minimize common side effects like redness, flaking, and irritation. The rule works by gradually increasing the frequency of application over a period of six weeks: 1 means applying retinol once a week for the first week; 2 means applying it twice a week for the next two weeks; and 3 means applying it three times a week for the following three weeks, after which you can try moving to every other night if your skin shows no sensitivity.
Does Perricone MD Have Retinol?
Does Perricone MD Have Retinol?
Yes, Perricone MD does have products that contain retinol, which Yes, Perricone MD does use retinol as a key active ingredient, primarily featuring it in their High Potency collection for powerful anti-aging results. They often use a proprietary “Triple Retinol Blend”—a mix of encapsulated retinol, retinol ester, and phyto-retinol—to accelerate skin renewal, reduce fine lines, and improve texture with potentially less irritation than traditional retinol formulas. Top products that contain this blend include the High Potency Triple Retinol Renewal Serum and the High Potency Retinol Recovery Overnight Moisturizer.
What is Perricone MD Cold Plasma?
What is Perricone MD Cold Plasma?
The Perricone MD Cold Plasma Plus+ collection is the brand’s signature line of multi-tasking skincare designed to address the nine most visible signs of healthy, youthful-looking skin in one comprehensive treatment. The core of the product line, particularly the Advanced Serum Concentrate, uses a proprietary liquid crystal delivery system to ensure key, potent ingredients are absorbed faster and deeper into the skin’s surface. These powerhouse ingredients include Copper Tripeptides for firmness, Vitamin C Ester for brightening, DMAE for lifting and toning, and omegas 3, 6, and 9 for moisture and barrier protection, all working together to visibly improve lines, wrinkles, uneven texture, uneven tone, discoloration, redness, enlarged pores, and loss of firmness.
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